Advances in osteoarthritis genetics: Table 1
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چکیده
منابع مشابه
Advances in osteoarthritis genetics
Osteoarthritis (OA), the most common form of arthritis, is a highly debilitating disease of the joints and can lead to severe pain and disability. There is no cure for OA. Current treatments often fail to alleviate its symptoms leading to an increased demand for joint replacement surgery. Previous epidemiological and genetic research has established that OA is a multifactorial disease with both...
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Osteoarthritis is a degenerative articular pathology with complex pathogeny because diverse factors interact causing a process of deterioration of the cartilage. In spite of the multifactorial nature of this pathology, from years 50 one knows that certain forms of osteoarthritis are related to a strong genetic component. The genetic bases of this disease do not follow the typical patterns of me...
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All animals use a sophisticated array of receptor proteins to sense their external and internal environments. Major advances have been made in recent years in understanding the molecular and genetic bases for sensory transduction in diverse modalities, indicating that both metabotropic and ionotropic pathways are important in sensory functions. Here, I review the historical background and recen...
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Some issues in quantitative genetics theory, other than molecular genetic analysis and utilisation, are reviewed. These include the development of models and methods for the analysis of longitudinal data, i.e. records continued or repeated over time, such as daily milk yield within and across lactation. The problems of identifying a range of alternative models and testing their fit are discusse...
متن کاملGenetics of osteoarthritis.
Osteoarthritis (OA) is a complex disease caused by the interaction of multiple genetic and environmental factors. This review focuses on the studies that have contributed to the discovery of genetic susceptibility factors in OA. The most relevant associations discovered until now are discussed in detail: GDF-5, 7q22 locus, MCF2L, DOT1L, NCOA3 and also some important findings from the arcOGEN st...
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ژورنال
عنوان ژورنال: Journal of Medical Genetics
سال: 2013
ISSN: 0022-2593,1468-6244
DOI: 10.1136/jmedgenet-2013-101754